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期刊名称：GENES & DEVELOPMENT ISSN： 0890-9369 版本： SCI-CDE 出版频率： Semimonthly 出版社： COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 500 SUNNYSIDE BLVD, WOODBURY, NY, 11797-2924   出版社网址： http://www.cshl.org/ 期刊网址： http://www.genesdev.org/ 影响因子： 13.623(2008) 主题范畴： DEVELOPMENTAL BIOLOGY;    GENETICS & HEREDITY 期刊简介(About the journal)    投稿须知(Instructions to Authors)    编辑部信息(Editorial Board)    About the journal Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D has an impact factor of 20.88, according to the 2001 Science Citation Index, released by the Institute for Scientific Information. This places G&D again among the top ten primary research journals in all fields of science. The journal is published in association with The Genetical Society of Great Britain. Instructions to Authors Genes & Development publishes high-quality research papers of general interest and biological significance in molecular and cell biology, and related areas. Genes & Development publishes two research manuscript formats: Research Papers and Research Communications, in addition to Review Articles and Perspectives. Research manuscripts must be submitted to the journal as either a Research Paper or Research Communication. Publication time from acceptance of manuscript is between one and three months. For papers accepted subject to revision, only one revised version will be considered; it must be submitted within 2 months of the provisional acceptance. Submission of Papers The journal accepts papers that present original research that has not been published previously. Submission to the journal implies that a paper is not being considered for another journal or book. Closely related papers that are in press elsewhere or that have been or will be submitted elsewhere must be included with the submitted manuscript. It is understood that researchers who submit papers to this journal are prepared to make available to qualified academic researchers materials needed to duplicate their research results (DNA, cell lines, antibodies, microbial strains, mice lines, etc.). Authors should submit nucleic acid and protein sequences, and X-ray crystallographic data to the appropriate database. Contributors from North and South America, Asia, and Australia must submit their papers to the Cold Spring Harbor Laboratory office (see address below). Contributors from Europe and Africa must submit their papers to the Munich office. Questions regarding papers should be directed to the Journals Office at Cold Spring Harbor Laboratory (516-422-4015). Online manuscript submission As of February 1, 2003, papers may be submitted by the author to our online manuscript submission system available at http://submit.genesdev.org. Files that are compatible with our system include: Word, WordPerfect, and PDF (Portable Document File). Image and table file formats accepted are GIF, TIFF, EPS, and JPEG. For tables, the system accepts most word processing formats as well; Please note:the system does not accept Excel files at this time. Please paste tables from Excel into a Word document format. Supplemental files may be submitted in any format. Supplemental files are not converted into a PDF with the text figures and tables and will be downloaded as needed. Please note: Files that CANNOT be used include: any Tex-type files, Bitmap (.bmp), PICT (.pict), photoshop (.psd), PowerPoint (.ppt), and CorelDRAW (.cdr). All figures files made with these programs should be converted to GIF, TIFF, EPS, or JPEG. We are also unable to accept Excel files(.xls) thus please convert from Excel to Word files. For additional information on submitting figures see "Electronic Art Submission" below. We hope you will find this new submission system helpful, and we look forward to receiving feedback so that we may continue to improve the system for manuscript submission and review. We are already working to increase the types of files we can accept. Alternatively, manuscripts may continue to be submitted as hard copies (see the following instructions). Manuscript Preparation Research Papers will occupy up to 12 journal pages and have a manuscript length of not more than 63,000 characters (including spaces). Abstracts will be limited to 200 words. A manuscript of 28-32 typed, double-spaced pages (including Materials and methods, References, Tables, and Figure legends) with a total of seven single-column (7.5 x 7.5 cm) figures and/or tables translates to 12 journal pages. Research Communications are high-quality, complete yet shorter bodies of work that provide compelling, novel, and important conclusions, and are of interest to a broad range of researchers. Thus, Research Communications may be more restricted in breadth of analysis and cover a more defined area of a particular field. However, the high standards of excellence by which the longer Research Papers are judged will be applied to Research Communications. Research Communciations may have a total manuscript length of no more than 35,000 characters (including spaces), and thus may not exceed six printed pages. This count includes: title, author’s names, affiliations, Abstract, key words, Results and Discussion, Materials and Methods, References, and Figure legends. Submit no more than five 3 x 3 inch (7.5 x 7.5 cm) figures and/or tables combined. (Note, multipart figures will be reduced to fit these dimensions.) If figures/tables are too large to be reduced to 3" x 3" (7.5 x 7.5 cm) size, you must either cut your text or submit fewer number of figures/tables. Please see G&D Worksheet for Sizing Research Communication Articles. Abstracts will be limited to 100 words or less. All research communications accepted after January 1, 2002 must have the Results and Discussion combined. Materials and methods will remain a separate section. References will be limited to no more than 40. The final version must meet the above guidelines. Manuscripts that do not conform to the appropriate format will be returned to the author. Manuscript Submission Online Submission: Manuscripts submitted online do not require hardcopies unless the editorial office requests them. Authors may submit manuscripts to our online system at http://submit.genesdev.org. Questions regarding online manuscript submission should be directed to the Journals Office at Cold Spring Harbor Laboratory (516-422-4015). Hard Copy Submission: Please submit five copies of the manuscript with original figures. All manuscript pages (including References, Tables, Figure legends, Footnotes) must be double-spaced and in a typeface of at least 11-point size. Label each page with the first author's name and page number. The cover letter should include: (a) the name, post and email addresses, and telephone and FAX number of the corresponding author; (b) a character count (including spaces) of the entire manuscript; (c) a statement that the manuscript has been seen and approved by all listed authors; (d) any specific requirements for art reproduction; and (e) the status of any permissions required. Any manuscript submitted by post must include a computer disk (3-1/2", zip, or CD) containing an electronic version of the manuscript and text and, preferably, as many figures and tables as possible. Please indicate the software programs used to generate the files. Form. Please observe the following order: Title page, Abstract, Introduction, Results, Discussion, Materials and Methods, Acknowledgments, References, Tables, Figure legends. The Title page should include: (a) title; (b) all authors' full names; (c) all affiliations clearly indicated; (d) a shortened version of the title for use as a running head (maximum 45 characters), and (e) up to six key words for use in indexing. Abstracts should summarize the aim of the report, the methodological approach, and the significance of the results. Methods should be detailed enough to allow qualified researchers to reproduce the results. Figures and legends. Manuscripts submitted by post must include five sets of figures as high-quality glossy prints. We also request that authors provide electronic copies of the figures with the manuscript (GIF, TIFF, EPS, or JPEG); this enables the staff to more quickly enter the manuscript into our online system and will expedite the conversion process. Har copy submissions lacking electronic figures will have their figures scanned. For the best reproduction, halftones should be high contrast. Line drawings, graphs, charts, and chemical formulae should be professionally prepared and labeled. Indicate magnification with a bar scale. Multipart figures should be submitted as one composite. Authors submitting color figures as essential data for review with manuscripts undertake to pay the publication costs of four-color artwork. Price estimates are supplied upon acceptance of the paper. Label the back of each figure with the first author's name, figure number, and an indication of "top." (Electronic copies should be labeled with the first authors name and the figure number, for example Smith_Fig1). Number figures consecutively in the order in which they are referred in the text. The figures sizes will be adjusted to fit the journal format; therefore, please keep labels, symbols, and other callout devices in proportion to the figure size and detail. Figure legends should be brief and should not contain methods. Symbols indicted in the figure must be identified in the legend text. If figures are reprinted from another source, permission to reprint is required. Tables. Tabular data should be presented concisely and logically. Number tables consecutively according to the order cited in the text. Provide a title for each table. Use only horizontal rules and ensure that column headings are unambiguous in indicating columns to which they refer. Include table legends and footnotes where needed. If tables are reprinted from another source or if data included are from another source, permission to reprint is required. References. Only those articles that are published or in press will be included in the references. Unpublished data, submitted manuscripts, or personal communications should appear in the text and should include first initials and last names of authors. References are name/date citations in text. Please note: the G&D reference style has changed. Please observe the following reference style: Pavio, A., Scharf, S., and Horn, G.T. 1975. Perceptual comparisons through the mind's eye. Mem. Cognit. 3: 635?647. Strunk, W. and White, E.B. 1979. The elements of style. Macmillan, New York, NY. Tymowska, J. 1991. Polyploidy and cytogenetic variation in frogs of the genus Xenopus. in Amphibian cytogenetics and evolution (ed, D.M. Green and S.K. Sessions), pp. 259?297. Academic Press, San Diego, CA. Proofs. Proofs are considered the final form of the paper and correction can be made only in the case of factual errors. If additional information must be added at this stage, it should be in the form of "Note added in proof," subject to the approval of the editors. Reprints. A reprint order form will be included with the proofs. To help defray the cost of publication, a charge of $30 per page will be made for publication in Genes & Development. Authors unable to meet these charges should include a letter of explanation upon acceptance for publication; inability to meet these charges will have no effect on acceptance and publication of submitted papers. Editorial Offices United States Genes & Development Cold Spring Harbor Laboratory Press 500 Sunnyside Boulevard Woodbury, NY 11797-2924 Phone 516-422-4015; FAX 516-422-4093 email genesdev@cshl.org Europe Genes & Development Gene Center and Institute for Biochemistry University of Munich Feodor Lynenstr. 25 81377 Munich, Germany Phone 49-89-2180-76902; FAX 49-89-2180-76947 email genesdev@lmb.uni-muenchen.de Electronic Art Submission: Detailed Instructions **Our printer can only accept electronic art as TIFF or EPS files. We also require two hardcopies of each figure at final acceptance to properly size and color match the electronic figures. Detailed instructions which may aid you in converting files to those suitable for processing by our printer are provided below. ** Please note we CANNOT accept Canvas, PowerPoint, SuperPaint, Corel Draw, Harvard Graphics, or Excel graphics because they are not compatible with our printer's output devices. If you have created your artwork electronically, please send the electronic files saved according to the detailed instructions below. 1. For final publication purposes, we can only accept electronic art as an EPS or TIFF file. See specific instructions below on saving your files in the most common programs. (For reviewing purposes, other file types are acceptable, as outlined above under manuscript submission.) 2. UPON FINAL ACCEPTANCE, AUTHORS MUST PROVIDE A GOOD CAMERA-READY COPY QUALITY PRINT WITH THEIR ELECTRONIC FILE for cases when electronic versions of the art fail, and as an additional check for the quality of the electronic version for publication. Always include a printout of the art at the same size it is saved on the disk. Do not enlarge or reduce the printout. This is important in case the electronic file can not be read and to make sure that the file on the disk is the same as the print provided. This printout is also used to size the artwork. If the art is in color, please provide a high quality color print so the print may be used as a guide to match the colors. Also, please note that our printer will not accept electronic artwork unless it is accompanied by high-quality reflective art as well. Both electronic and reflective art need to match each other exactly. 3. Please make sure that your files are properly labeled by first author's name/figure number (for example, Smith_Fig1, Smith_Fig5) and that printouts are properly labeled and correspond to the file name. Also indicate the programs used to generate the artwork. 4. Send only final electronic art files. DO NOT EMBED FIGURES WITHIN THE MANUSCRIPT TEXT FILES. 5. Use Helvetica typeface in point sizes no smaller than 8 pt and no larger than 10 pt, except for the main callouts (e.g. A, B, C), which should be 12 pt. Generating Electronic Artwork from Original Glossy Prints (For artwork that was not created electronically for which you wish to provide an electronic version) All photographs need to be scanned at a resolution of at least 350 dpi. Photographs should be saved as a TIFF file (not EPS) in Photoshop. If the figure is in color, make sure it is converted to CMYK (not RGB or Pantone) and follow specifications below for color art. If the artwork that contains the photograph also contains line art (even one or two text characters), you need to follow the specifications below for combo art. When in doubt with halftone art, please follow the specs for combo art. All line art figures need to be scanned at a resolution of at least 1200 dpi in bitmap mode (there are no halftone dots in line art). Line art should be saved as EPS files. If the line art is in color, make sure it is converted to CMYK (not RGB or Pantone) and follow specifications below for color art. All combo art (which includes within the artwork both halftones/grayscale and line art) must be 900 dpi in grayscale mode and saved as TIFF files. All color art should be scanned or produced at 350 dpi in CMYK mode and saved as TIFF files. Always save your color scans into the CMYK color space. Never submit color electronic files in RGB mode. Submission of Artwork that has been Created using Photoshop and Illustrator Programs Please send us the original electronic files for any artwork that has been created using these programs. In order to use these files, please save the files using the specific instructions below. Once again, please note we CANNOT accept Canvas, PowerPoint, SuperPaint, Corel Draw, Harvard Graphics, or Excel graphics because they are not compatible with our printer's output devices. Adobe Illustrator 1. Under the File menu, choose save as, format (Illustrator EPS) 2. Click save and a window will come up 3. Click compatibility 6.0 4. Under options, click include document fonts and click include document thumbnails 5. Preview should be checked as 8-bit Macintosh 6. Click okay 7. In case we have trouble with your file, please download all fonts that were used in creating your artwork onto the disk . The preview box is very important. Make sure it is checked off as 8-bit Macintosh. If the artwork is in color, please make sure to create the artwork using CMYK colors. If TIFF images are transferred into Illustrator, please make sure to supply the TIFF images separately on the disk as well. Create a folder on the disk labeled (Illustrator TIFFs). When saving the file, make sure "include placed files" is checked in the options box. Adobe Photoshop 1. Under the File menu, choose save as, format (TIFF) 2. Click save 3. Under TIFF options check Macintosh, do not check LZW compression 4. Click okay Do not save your files as EPS files. If the artwork is in color, please make sure to create the artwork using CMYK colors (not RGB or Pantone colors). Please make sure the resolution is at 350 dpi and saved as a TIFF file.   If you have any questions on how to save your artwork, please contact the US office at genesdev@cshl.org.   A Word About Electronic Art Submission: Cold Spring Harbor Laboratory Press makes every effort to use the electronic files from the authors. We are well equipped and trained with many of the graphics software programs that are used in the scientific community. Adobe Illustrator 6.0 or newer, Adobe Photoshop 4.0 or newer, and Macromedia Freehand 7.0 or newer are the main "true" graphics programs that all publishers and printing industries support. The file formats generated by these programs are universal and can easily be read by high-end imagesetters. Canvas, Corel Draw, Powerpoint, Harvard Graphics, and SuperPaint are typical graphics programs that excel at creating visual presentations, such as slides, and overheads. However, they do not always export in file formats that can be printed through high-end imagesetters. Printers print in CMYK. Most authors submit their files in RGB. When these files are converted to printing industry standards, the colors often change completely. This is why it is very important for the artwork to be created as CMYK and for a hard copy of the artwork to be submitted for comparison. In the event that we cannot use the electronic file, a film from the hard copy image will be created. As noted elsewhere above, our printer will not accept a digital art file unless it is also accompanied by high-quality reflective art that matches exactly. It should be stressed again that electronic figures must be submitted using either Illustrator or Photoshop. We hope the other graphics programs will eventually support printing industry standards as well. Editorial Board J. Adams (Melbourne, Australia) A. Amon (Cambridge, USA) Y.-A. Barde (Basel, Switzerland) D. Barford (Oxford, UK) C. Bargmann (San Francisco, USA) S. Bell (Cambridge, USA) A. Berns (Amsterdam, The Netherlands) M. Bienz (Cambridge, UK) T. Cech (Boulder, USA) P. Chambon (Strasbourg, France) N.-H. Chua (New York, USA) S. Courtneidge (Grand Rapids, USA) R. Davis (Worcester, USA) S. Elledge (Houston, USA) R. Evans (La Jolla, USA) G. Fishell (New York, USA) E. Fuchs (New York, USA) S. Gottesman (Bethesda, USA) C. Gross (San Francisco, USA) M. Groudine (Seattle, USA) L. Guarente (Cambridge, USA) E. Hafen (Zurich, Switzerland) S. Hake (Albany, CA USA) A. Hall (London, UK) R. Harland (Berkeley, USA) N. Hastie (Edinburgh, UK) A. Hinnebusch (Bethesda, USA) J. Hodgkin (Oxford, UK) B. Hogan (Durham, USA) P. Ingham (Sheffield, UK) S. Jackson (Cambridge, UK) Y.-N. Jan (San Francisco, USA) K. Jones (La Jolla, USA) J. Kadonaga (La Jolla, USA) R. Klein (Heidelberg, Germany) J. Kuriyan (Berkeley, USA) M. Levine (Berkeley, USA) D. Livingston (Boston, USA) R. Losick (Cambridge, USA) V. Lundblad (Houston, USA) J. Manley (New York, USA) M. Mathews (Newark, NJ USA) S. McKnight (Dallas, USA) A. McMahon (Cambridge, USA) N. Perrimon (Boston, USA) C. Prives (New York, USA) D. Reinberg (Piscataway, USA) U. Schibler (Geneva, Switzerland) P. Sharp (Cambridge, USA) C. Sherr (Memphis, USA) S. Smale (Los Angeles, USA) D. Solter (Freiburg, Germany) P. Soriano (Seattle, USA) J. Steitz (New Haven, USA) P. Sung (New Haven, USA) M. Takeichi (Kyoto, Japan) T. Taniguchi (Tokyo, Japan) R. Tjian (Berkeley, USA) D. Weigel (Tubingen, Germany) Editors T. Grodzicker (Cold Spring Harbor) R. Grosschedl (Munich) Assistant Editor M. McDonough (Cold Spring Harbor) Editorial Assistant H. Cosel-Pieper (Cold Spring Harbor) Editorial/Production L. Sussman, Production Manager C. Blaut, Production Editor P. Henick, Production Assistant B. Garite, Editorial Secretary Editorial Offices United States Genes & Development Cold Spring Harbor Laboratory Press 500 Sunnyside Boulevard Woodbury, New York 11797 Phone: 516-422-4015; FAX: 516-422-4093 e-mail: genesdev@cshl.org Web site: http://www.genesdev.org Europe Genes & Development Gene Center and Institute for Biochemistry University of Munich Feodor Lynenstr. 25 81377 Munich, Germany Phone: 49-89-2180-76902; FAX: 49-89-2180-76947 e-mail: genesdev@lmb.uni-muenchen.de