期刊名称：CHIRALITY
 期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
Aims and Scope
The main aim of the journal is to publish scientific work on the role of molecular asymmetry in both biologically active and non-biologically active molecules in respect to their pharmacological, biological, and chemical properties. Drugs, pesticides, and other xenobiotics will be a major interest.
Papers on the chemistry (physiochemical, preparative synthetic, and analytical), pharmacology, clinical pharmacology, toxicology, and other biological aspects of chiral molecules will be published.
Among the topics to be covered are stereospecific synthesis, stereoselective analysis, preparative separation of chiral molecules, the influence of chirality on pharmacokinetics (absorption, distribution, protein binding, biotransformation, etc.), the influence of chirality on pharmacodynamics (drug-receptor interactions, pharmacological and toxicological activity), and the influence of chirality on clinical pharmacology (therapeutic index and response, bioavailability, adverse drug reactions, drug-drug interactions). Papers will also be published on regulatory and legal aspects in the development, testing, and marketing of chiral compounds.
In addition to original research papers, the journal will publish brief reviews, short communications, and conference reports. Book reviews will also appear.
Instructions to Authors
Manuscripts
In order to expedite the peer review process, authors are encouraged to submit their manuscripts in PDF. Upon acceptance, authors must provide the word processing file of the final version of the accepted manuscript. Please refer to the section on Disk Submission Instructions. All manuscripts must be typewritten, double spaced, and they must be in English. Authors in Japan please note: Wiley-Japan can provide authors in Japan with a list of recommended services to check and improve the English in their papers BEFORE SUBMISSION. Please contact Masayo Kobayashi in the Wiley-Japan office by Fax: 81 3 3556 9763 or e-mail: editorial@wiley.co.jp for more information. Submit the original and two copies (including tables and illustrations) on one side of good quality 8 1/2 x 11 inch paper with at least one inch margins. Number all pages in sequence, beginning with the title page. Follow the guidelines in ACS Style Guide (except for references and abbreviations as noted below), available from the American Chemical Society, 1155 Sixteenth Street, N.W., Washington, DC 20036. The text should conform to the following format:
Title Page. This must contain: (1)complete title of the manuscript; (2)author's name(s) must carry superscript number(s). The corresponding author should be indicated by an asterisk; (3) institutional affiliation(s) (at which the work was performed) must be listed at the departmental level. Each distinct affiliation should be listed as a separate entity, with a superscript number that links it to the individual author(s); (4) shortened title which does not exceed 45 characters, including spaces, to be used as a running head; (5) five to ten key words not used in the title that will adequately index the subject matter of the article; (6) current and complete name, address, phone and fax numbers, and E-mail address of the corresponding author; (7) all grant information should be provided in the following format: Contract grant sponsor:__________; Contract grant number:________.
Abstract. This should summarize the purpose, methods, results, and major conclusions of the work in fewer than 200 words.
Introduction, Materials and Methods, Results, Discussion, and Conclusion. These should conform to standard scientific reporting style. Sufficient data must be given so that the study can be replicated. It may be appropriate to combine the Results and Discussion.
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References to published literature should be cited in the text numerically. Reference should be made only to articles that are published or in press. Unpublished results and personal communications should be cited parenthetically in the text and should not be included in the Reference list. Authors are responsible for the accuracy of the references. It is important to provide full titles and complete page ranges for all works cited in the reference section. Do not include footnote information in the References. Footnote information should either be incorporated into the text or included as a footnote to the text. If applicable, a footnote with the following statement should be included at an appropriate place in the manuscript: Crystallographic data for the structure(s) reported in this paper have been deposited with the Cambridge Crystallographic Data Centre (insert CCDC #). Copies of the data can be obtained, free of charge, on application to the Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, United Kingdom (Fax: 44-1223-336033 or e-mail: deposit@ccdc.cam.ac.uk).
Journal
1. King VM, Armstrong DM, Apps R, Trott JR. Numerical aspects of pontine, lateral reticular, and inferior olivary projections to two paravermal cortical zones of the cat cerebellum. J Comp Neurol 1998;390:537-551.
When references are made to more than one paper by the same author, published in the same year, designate them as a, b, c, etc.
2. Dewar MJS, Zoebisch EG, Healy EF, Stewart JJP. AM1: A new general purpose quantum mechanical model. J Am Chem Soc 1985a;107:3902-3909.
3. Dewar MJS, Yuan Y-C. AM1 parameters for sulfur. Inorg Chem 1985b;29:3881-3890.
4. Dewar MJS, Zoebisch EG. Extension of AM1 to the halogens. THEOCHEM 1985c;49:1-21.
Books
5. Voet D, Voet JG. Biochemistry. New York: John Wiley & Sons; 1990. 1223 p.
Book Chapter
6. Gilmor ML, Rouse ST, Heilman CJ, Nash NR, Levey AI. Receptor fusion proteins and analysis. In: Ariano MA, editor. Receptor localization. New York: Wiley-Liss;1998. p 75-90.
Tables and Illustrations
Indicate placement of all tables and illustrations at the relevant point in the text. Tables must be numbered in order of appearance with Roman numerals; illustrations with arabic numerals. A legend must accompany each illustration (including schemes), and tables must have titles. Type double spaced. All abbreviations used must be defined. Lettering must meet professional standards and be legible after reduction in size. Identify all illustrations by affixing a gummed label on the back listing the number of the illustration, first author's name, short title of the manuscript, and an arrow indicating the top. Do not submit original recordings, radiographic plates, or artwork. All color figures will be reproduced in full color in the online edition of the journal at no cost to authors. Authors are requested to pay the cost of reproducing color figures in print. Authors are encouraged to submit color illustrations that highlight the text and convey essential scientific information. For best reproduction, bright, clear colors should be used. Dark colors against a dark background do not reproduce well; please place your color images against a white background wherever possible. Please contact Carol Ann McNelis at 201-748-6009/cmcnelis@wiley.com for further information.
Abbreviations
All nonstandard abbreviations and acronyms should be spelled out at the point of first use in the abstract and the body of the text. Units of length, area, volume, weight, and time are to be abbreviated as follows:
(For Area and Volume insert the appropriate exponent)
| km |
kilometer |
kl |
kiloliter |
| m |
meter |
ml |
milliliter |
| cm |
centimeter |
祃 |
microliter |
| mm |
millimeter |
nl |
nanoliter |
| 祄 |
micrometer |
pl |
picoliter |
| nm |
nanometer |
liter |
do not abbreviate |
| pm |
picometer |
| ? |
angstrom |
| kg |
kilogram |
yr |
year |
| g |
gram |
mo |
month |
| mg |
milligram |
wk |
week |
| 礸 |
microgram |
day |
do not abbreviate |
| ng |
nanogram |
h |
hour |
| pg |
picogram |
min |
minute |
|
|
sec |
second |
Stereochemical Nomenclature
The guidelines for stereochemical nomenclature used in this journal are presented below. For compounds which are not covered by these guidelines follow the ACS Style Guide.
Apparently Pure Stereoisomers. These must be designated by the sign of their optical rotation (when applicable) and/or by their configuration (absolute configuration in the case of enantiomerism, relative configuration in the case of diastereomerism).
The sign of the optical rotation is indicated by (+)- or (?- placed at the very beginning of the name, i.e., before the descriptor of configuration. The signs d- and l- are not allowed as they are frequently confused with D- and L-. The prefixes "dextro" and "levo" are allowed when they form part of an established name (e.g., levodopa).
The absolute configuration of enantiomers must be given as far as known. Descriptors of absolute configuration are as follows:
?I>R and S defined according to the sequence rule of Cahn-Ingold-Prelog
旸 and L (for amino acids and sugars)
?I>P and M (for helices)
The relative configuration of diastereomers must be indicated as follows:
旻or  -diastereomers (so-called geometrical isomers), the E and Z descriptors based on the sequence rule of CIP must be used rather than the prefixes cis and trans or syn and anti.
旻or achiral diastereomers without stereogenic double bonds ( -diastereomers), be they cyclic or acyclic, adequate nomenclature, cis and trans, erythro and threo, or meso, must be used.
旻or chiral s-diastereomers (cyclic or acyclic), the absolute configuration of each element of chirality should be indicated when known. If this is not the case, the relative configuration must be indicated (e.g., cis/trans, erythro/threo, endo/exo, R*/S*,  / ).
Examples follow:
(+)-(R)-warfarin
(Z)-2-methyl-2-butenoic acid
(?-(P)-hexahelicene
cis-1,2-dichlorocyclohexane
(?-(1R;2R)-pseudoephedrine
trans-decalin
Further indications can be found in the IUPAC rules or in monographs (e.g., Eliel, E.L. and Wilen, S.H., Stereochemistry of organic compounds. New York: Wiley, 1994).
Mixtures of Stereoisomers
Racemates must always be explicitly indicated as such using the prefix rac杄.g., rac-ibuprofen.
Mixtures of diastereomers must be indicated by such notation as (Z;E)- or cis-, trans- which do not imply a 50/50 mixture. When a mixture of stereoisomers has a well-defined proportion, this must be specified as in the following examples:
?R/S:80/20)-warfarin
?Z/E:90/10)-clopenthixol
Structural Formulas of Stereoisomers
Special attention must be given to the preparation of the structural formulas of compounds that contain stereogenic elements. For substituents that point toward or away from the observer, use flying wedges and dotted lines, respectively.
Each structural formula must be accompanied by an explicit caption indicating whether the formula implies absolute or relative configuration.
Electronic Proofing
In order to expedite the publication and on-line posting of articles in Wiley InterScience, Chirality now offers electronic proofing. Corresponding authors with e-mail addresses will be sent page proofs (and paperwork, such as reprint order forms) in pdf format via e-mail. Please follow the instructions in the e-mail; contact names and numbers are given for questions, problems, or if an author wishes to receive a paper proof. A fax cover form with the Production Editor抯 information is also provided for authors to fax their corrections. Please notify us of your preferred proof delivery method when submitting your final manuscript to the editorial office. Indicate in your cover letter your page proof choice: ELECTRONIC (pdf) or TRADITIONAL (paper).
Copyright
All Manuscripts submitted to Chirality must be submitted solely to this journal, and may not have been published in another publication of any type, professional or lay. Upon acceptance of a manuscript for publication, the author will be requested to sign an agreement transferring copyright to the publisher, who reserves copyright. No published material may be reproduced or published elsewhere without the written permission of the publisher and the author. The journal will not be responsible for the loss of manuscripts at any time. All statements in, or omissions from, published manuscripts are the responsibility of the authors, who will assist the editors by reviewing proofs before publication. Reprint order forms will be sent with the proofs.
Instructions for Deposition of Cystallographic Data
(i) These notes concern the crystallographic data associated with organic and metal-organic structures.
(ii) Prior to submitting the manuscript to a journal the author should deposit with the Cambridge Crystallographic Data Centre (CCDC) the data corresponding to the intended publication.
The preferred mode of deposition is by e-mail as a plain text ASCII file. Wherever possible the CIF format should be used but other formats will be accepted. The e-mail address is: deposit@ccdc.cam.ac.uk
(iii) Within three working days, the CCDC will provide the author with a deposition number for each crystal structure reported in the manuscript. Each number is a 6-digit integer, e.g., CCDC 170345.
(iv) The author should submit to the journal the manuscript together with the deposition number(s).
(v) When the paper is published an appropriate footnote will be printed, for example:
"CCDC ...... contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/retrieving.html (or from the Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033; or deposit@ccdc.cam.ac.uk)"
(vi) The deposited data will not be archived to the Cambridge Structural Database until the paper has been published. If, after 18 months, the paper has not been published, the CCDC will contact the depositor to determine what should be done with the data.
Notes for Authors: Guidance for deposition can be obtained from www.ccdc.cam.ac.uk/conts/depositing.html
Author Submission Guidelines for Supplementary Material
Chirality authors can now publish supplementary material online in Wiley InterScience. Supplementary material may include (but is not limited to) video clips, large sections of tabular data, program code, or electronic graphical files that are otherwise not suitable for print media. When submitting material for consideration please follow the guidelines below.
Submission of Supplementary Material
Peer review: Supplementary material must be submitted at the time of peer review. Submit a paper copy of the material (in the case of material that exists in electronic form only, please consult the editor to whom you submitted the paper).
Acceptance and electronic submission: Once material has been accepted by the editors, it must be submitted in electronic form on PC or Macintosh 3.5" diskette, zip disk, or CD ROM, or via FTP to ftp.wiley.com (user ID chiral password diff&4; see FTP submission notes below).
All files submitted must be accompanied by a text file named README. The README file should include the following information:
Title of Paper
Authors and their affiliations
Filename, file size, file type
Brief description of material
The data and the README file should be archived together using one of the popular archive protocols such as ZIP, TAR, GZIP, or SIT. If you have more than one piece of supplementary material, you should submit a separate archive for each, with an accompanying README file; however, if it is intended that the multiple files be downloaded as a single unit by the enduser, submit one archive and one README file.
Data file types: There are no restrictions on filetypes of the data that you submit. Please keep in mind, however, that the more universal the filetype the more accessible to the community. The use of popular compression protocols is highly encouraged. If your material is presented in PostScript format, the submission of an accompanying Adobe Acrobat PDF file is encouraged, in that event both formats will be offered to the journal's readers. In cases where PDF files do not accompany a PostScript file, only the Postscript will be offered.
FTP Submission Notes: Submission of accepted material via FTP is encouraged. The FTP address is ftp.wiley.com. When prompted for username enter chiral. When prompted for password enter diff&4. This will lead to a directory reserved for Chirality uploads. You will not be able to see a listing of the files in this directory, including the ones that you upload.
Please note: The upload area allows upload only and does not allow downloads. When the FTP is complete, alert the publisher via an email to cmcnelis@wiley.com. Include your name and the name(s) of the files that you uploaded.
Publication and Access
Supplementary material for published articles will be made available via the Chirality World Wide Website (http://www.interscience.wiley.com/chirality). Click on the 揝upplementary Material?link, which will bring you to a page that lists all supplementary material by journal volume. The title, authors, and volume/page number will in turn be hyperlinked to a page that describes the material in detail and offers a FTP download hyperlink. In addition, a hyperlink in the article抯 abstract online and a footnote in the printed article抯 title page will lead the reader to the supplementary material.
Disk Submission Instructions
Please return your final, revised manuscript on disk as well as hard copy.
The hard copy must match the disk.
The journal strongly encourages authors to deliver the final, revised version of their accepted manuscripts (text, tables, and, if possible, illustrations) on disk. Given the near-universal use of computer word-processing for manuscript preparation, we anticipate that providing a disk will be convenient for you, and it carries the added advantages of maintaining the integrity of your keystrokes and expediting typesetting. Please return the disk submission slip below with your manuscript and labeled disk(s).
Guidelines for Electronic Submission
Text
Software and format. Microsoft Word is preferred, although manuscripts prepared with any other word processor are acceptable. Refrain from complex formatting; the publisher will style your manuscript according to the journal design specifications. Do not use desktop publishing software such as Aldus PageMaker or Quark XPress. If you prepared your manuscript with one of these programs, export the text to a word processing format. Please make sure your word-processing program's "fast save" feature is turned off. Please do not deliver files that contain hidden text: for example, do not use your word processor's automated features to create footnotes or reference lists.
File names. Submit the text and tables of each manuscript as a single file. Name each file with your last name (up to eight letters). Text files should be given a three-letter extension that identifies the file format. Macintosh users should maintain the MS-DOS "eight dot three" file-naming convention.
Labels. Label all disks with your name, the file name, and the word processing program and version used.
Illustrations
All print reproduction requires files for full color images to be in a CMYK color space. If possible, ICC or ColorSync profiles of your output device should accompany all digital image submissions.
Storage medium. Submit as separate files from text files, on separate disks or cartridges. If feasible, full color files should be submitted on separate disks from other image files. 3-1/2" disks, CD, or Iomega Zip disks can be submitted. At authors' request, disks will be returned after publication.
Software and format. All illustration files should be in TIFF or EPS (with preview) formats. Do not submit native application formats.
Resolution. Journal quality reproduction will require greyscale and color files at resolutions yielding approximately 300 ppi. Bitmapped line art should be submitted at resolutions yielding 600-1200 ppi. These resolutions refer to the output size of the file; if you anticipate that your images will be enlarged or reduced, resolutions should be adjusted accordingly.
File names. Illustration files should be given the 2- or 3-letter extension that identifies the file format used (i.e., .tif, .eps).
Labels. Label all disks and cartridges with your name, the file names, formats, and compression schemes (if any) used. Hard copy output must accompany all files.
Print and return with labeled diskette(s)
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Corresponding author's name:
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E-mail address:
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Telephone:
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Manuscript number:
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Type of computer:
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Program(s) & version(s) used:
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Miscellaneous:
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I certify that the material on the enclosed diskette(s) is identical in both word and content to the printed copy herewith enclosed.
Signature: ______________________________________________ Date: _____________
Editorial Board
Editors
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Associate Editor
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Prof. John CaldwellFaculty of Medicine University of Liverpool Duncan Building Daulby Street Liverpool L69 3GA, United Kingdom E-mail: jcc@liverpool.ac.uk |
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Prof. Nobuyuki HaradaInstitute of Multidisciplinary Research for Advanced Materials Tohoku University Aoba, Sendai, Japan E-mail: n-harada@tagen.tohoku.ac.jp |
E D I T O R I A L B O A R D
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Dr. Hassan Y. Aboul-Enein
Drug Development Laboratory
King Faisal Specialist Hospital and Research Center
Riyadh, Saudi Arabia
Prof./Dr. Stig G. Allenmark
Department of Organic Chemistry
Goteborg University
Goteborg, Sweden
Prof. Daniel W. Armstrong
Department of Chemistry
Iowa State University
Ames, IA, USA
Dr. William F. Bailey
Department of Chemistry
University of Connecticut
Storrs, CT, USA
Dr. Carlo Bertucci
Dipartimento di Scienze Farmaceutiche
University of Bologna
Bologna, Italy
Prof. Dr. Gottfried Blaschke
Institute of Pharmaceutical Chemistry
Westfalische Wilhelms-University of M黱ster
M黱ster, Germany
Prof. D. Boyd
School of Chemistry
The Queen's University of Belfast
Belfast, United Kingdom
Dr. Harry Brittain
Center for Pharmaceutical Physics
Milford, NJ, USA
E-mail: Hbrittain@earthlink.net
Prof. Herbert C. Brown
Purdue University
West Lafayette, IN, USA
E-mail: hcbrown@chem.purdue.edu
Prof. James W. Canary
Department of Chemistry
New York University
New York, NY, USA
E-mail: canary@canarylab.chem.nyu.edu
Prof. Vadim A. Davankov
Institute of Organo-Element Compounds
Academy of Science
Moscow, Russia
Prof. Huw M.L. Davies
Department of Chemistry
State University of New York (SUNY) at Buffalo
Buffalo, NY, USA
Dr. Wilson H. DeCamp
Center for Drug Evaluation and Research
U.S. Food and Drug Administration
Rockville, MD, USA
E-mail: decamp@cder.fda.gov
Dr. Lorenzo Di Bari
Dipartamento Di Chimica Ind.
Universita di Pisa
Pisa, Italy
E-mail: lorenzo@dcci.unipi.it
Dr. W.L. Duax
Molecular Biophysics Department
Hauptman-Woodward Medical
Research Institute, Inc.
Buffalo, NY, USA
Prof. Anthony F. Fell
School of Pharmaceutical Chemistry
University of Bradford
Bradford, United Kingdom
Prof./Dr. August W. Frahm
Pharmazeutisches Institut
Universitat Freiburg
Freiburg, Germany
E-mail: awfrahm@sun2.ruf.uni-freiburg.de
Dr. Eric Francotte
Novartis AG Basel
Basel, Switzerland
Prof. Jacek Gawronski
Department of Chemistry
University Adam Mickiewicz
Poznan, Poland
E-mail: gawronsk@vm.amu.edu.pl
Dr. Jorgen Hermansson
ChromTech AB
Hagersten, Sweden
Dr. Fakhreddin Jamali
Faculty of Pharmacy and Pharmaceutical Sciences
University of Alberta
Edmonton, Alberta, Canada
Prof. Yasuyuki Kita
Graudate School of Pharmaceutical Sciences
Osaka University
Suita, Osaka, Japan
E-mail: kita@phs.osaka-u.ac.jp
Dr. Dilip Kondepudi
Department of Chemistry
Wake Forest University
Winston-Salem, NC, USA
Prof./Dr. Wilfried Konig
Institut f r Organische Chemie
Universitat Hamburg
Hamburg, Germany
Prof. Povl Krogsgaard-Larsen
Department of Medicinal Chemistry
The Royal Danish School of Pharmacy
Copenhagen, Denmark
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Dr. Wolfgang Lindner
Institute of Analytical Chemistry
University of Vienna
Wien, Austria
Dr. Kenny Lipkowitz
Department of Chemistry
North Dakota State University
Fargo, ND, USA
Prof. Albrecht Mannschreck
Institute for Organic Chemistry
University of Regensburg
Regensburg, Germany
Prof. Stefan Matile
Department of Organic Chemistry
University of Geneva
Geneva, Switzerland
E-mail: stefan.matile@chiorg.unige.ch
Dr. Ray McCague
Chirotech Technology Ltd.
Cambridge, United Kingdom
Prof. Koichi Mikami
Department of Chemical Technology
Tokyo Institute of Technology
Tokyo, Japan
E-mail: kmikami@o.cc.titech.ac.jp
Prof. Domenico Misiti
Laboratory of Organic Chemistry
University of Rome
Rome, Italy
Prof. Terumichi Nakagawa
Graduate School of Pharmaceutical Sciences
Kyoto University
Kyoto, Japan
E-mail: nakagawa@pharm.kyoto-u.ac.jp
Prof. Koji Nakanishi
Department of Chemistry
Columbia University
New York, NY, USA
Dr. Y. Okamoto
Department of Synthetic Chemistry
Nagoya University
Chikusa, Nagoya, Japan
Prof. Popat Patil
College of Pharmacy
Ohio State University
Columbus, OH, USA
Prof. William H. Pirkle
School of Chemical Sciences
University of Illinois,
Urbana, IL, USA
Prof. Prasad Polavarapu
Department of Chemistry
Vanderbilt University
Nashville, TN, USA
E-mail: prasad.l.polavarapu@vanderbilt.edu
Prof. Carlo Rosini
Dipartamento di Chimica
Universita della Basilicata
Potenza, Italy
Prof. Kazuhiko Saigo
Department of Chemistry and Biotechnology
Graduate School of Engineering
The University of Tokyo
Tokyo, Japan
E-mail: saigo@k.u-tokyo.ac.jp
Prof. Piero Salvadori
Institute of Chemistry
University of Pisa,
Pisa, Italy
Prof. Volker Schurig
Institut fur Organische Chemie
Universit鋞 T黚ingen
T黚ingen, Germany
Dr. Rashmi R. Shah
Medicines Control Agency
London, United Kingdom
E-mail: rashmi.shah@mca.gov.uk
Prof. Barry Sharpless
Scripps Research Institute
La Jolla, CA, USA
Dr. Apryll Stalcup
Department of Chemistry
University of Cincinnati
Cincinnati, OH, USA
Dr. Bernard Testa
University of Lausanne
Lausanne, Switzerland
Dr. Irving W. Wainer
Bioanalytical Center
Department of Pharmacology
Georgetown University Medical Center
Washington, DC, USA
Dr. Christopher J. Welch
Merck & Co., Inc.
Rahway, NJ 07065
Dr. Ken Williams
Department of Clinical Pharmacology
St. Vincent's Hospital
Darlinghurst, Australia
E-mail: ken.williams@unsw.edu.au
Prof. Peter Wipf
Department of Chemistry
University of Pittsburgh
Pittsburgh, PA, USA
E-mail: pwipf@vms.cis.pitt.edu
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刊名字顺( Alphabetical List of Journals):
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