期刊名称：SCIENCE SIGNALING
 期刊简介(About the journal)
投稿须知(Instructions to Authors)
编辑部信息(Editorial Board)
About the journal
Science Signaling is a weekly journal, publishing 51 issues a year, as well as an online resource and information management tool that enables experts and novices in cell signaling to find, organize, and utilize information relevant to processes of cellular regulation. The overarching goal of Science Signaling is to identify and develop a mix of tools and approaches (algorithms, schemas, programs, and human organizational structures) that are stable, scalable, interoperable, and cost effective for providing access to information on cell signaling. All aspects of Science Signaling are designed to facilitate the site's main purpose, which is to maximize the efficiency with which the reader gathers, assimilates, and understands information about cell regulatory processes. We strive to increase the likelihood of the scientist making new connections between facts from discrete sources, and to support educational, collaborative, and community-building efforts. An additional goal of the site is to provide a database of cell signaling information with information supplied by scientific experts, as well as to develop the tools and organizational structures needed to undertake this project and present the results for both human readers and computer-based analysis.
Experienced editors from Science worked with software developers from HighWire Press to develop the knowledge environment, which includes information management tools that researchers indicated they needed. Science Signaling emphasizes information selected and vetted by authorities in the field, prudently supplemented with automated functions where appropriate. The high editorial standards that have been the benchmark for Science are applied to selection of material for Science Signaling.
More detailed information about the articles and resources of Science Signaling can be found in the corresponding Help sections. A brief description is provided below.
Science Signaling: Original Articles
Science Signaling is adding original Research Articles to the weekly journal. Science Signaling will publish research that represents a major advance in cell signaling, including key research papers in the rapidly expanding areas of signaling networks, systems biology, synthetic biology, computation and modeling of regulatory pathways, and drug discovery. Papers will be selected for publication in Science Signaling on the basis of their importance and broad interest to scientists engaged in the general area of cellular regulation as determined by the editors in consultation with a Board of Reviewing Editors and in-depth reviewers of papers. Acceptable papers should substantially refine current understanding of important signaling processes with priority given to those papers that the reviewers and editors determine to provide new concepts and new understanding of biological signal transduction and that are likely to find application multiple biological systems or in a diverse range of investigations.
Science Signaling publishes original Perspectives, Reviews, and Protocols, most of which are solicited by the editors. Perspectives present the opinion of the author focused on one main issue, often a new development from a published paper or group of papers. Meeting Reports and Book Reviews also appear in the Perspectives section. Reviews are more complete analyses of topics of broad interest and are critically peer reviewed for scholarship, clarity, and accuracy. Protocols are presented in detail with background information for interested readers who may not intend to actually use the protocol and with detailed instructions and troubleshooting guides for readers who do wish to apply the technique.
Science Signaling: Resources for Education
The Teaching Resources, Glossary, and Journal Club sections of Science Signaling provide information, materials, and articles that enable students and educators to better understand and teach the complex topic of cell signaling. The Teaching Resources include diverse materials that aid in teaching topics or courses in cell signaling, such as lecture notes and slides, syllabi, research projects, experiments, animations, discussions, and online tutorials. These resources are intended to facilitate in the instruction of complicated biological mechanisms and theories, as well as to encourage active student discussion and participation. The Glossary provides definitions for acronyms, abbreviations, and other cell signaling terms commonly found in Science Signaling articles and resources. The definitions are provided by the editors based on the usage of the terms in Science Signaling articles; when available, terms have links to more detailed information in the Database of Cell Signaling. Journal Club articles are brief pieces that highlight recent exciting developments in cell signaling research and are written by graduate students or postdoctoral fellows with little or no input from a senior author. These articles allow the new generation of signaling researchers to gain experience in critical analysis of the recent literature and in the process of scientific communication, while providing the readers a fresh view of cell signaling research.
Science Signaling: The Virtual Journal
Nineteen publishers have agreed to include full-text access to signal transduction articles from their journals in the Science Signaling Virtual Journal. Daily, semantic indexing software analyzes the contents of the latest issues of participating journals, identifies the signal transduction-related articles, and adds these to the Virtual Journal. The automatic indexing process is supplemented by editorial oversight to add articles missed by the algorithm or to remove articles that are not relevant to the field of cell signaling.
Science Signaling: Current Awareness and Personalization
My Science Signaling provides customization features to tailor the site to the user's needs and interests (these features require personal subscription or registration and access through an institutional site license). Science Signaling offers eTOC alerts (alerting users when a new issue of Science Signaling is published), as well as three types of CiteTrack research alerts: (i) keyword alerts, alerting users when new original Science Signaling articles or articles in the Virtual Journal are published, or resources in the Community and Resources sections of the site are added that contain the specified keywords; (ii) author alerts, alerting users when articles by the specified authors are added to Science Signaling; and (iii) citation alerts, alerting users when a specified article is referenced by another article published in a journal hosted by HighWire Press.
In addition to these user-specified current awareness tools, each week the editors of Science Signaling scan the literature for newly published papers of particularly broad interest. Brief summaries of the selected papers are presented in Editors' Choice.
Users can organize information found at the site into Folders. My Display Settings provide personalized filters for searches that allow individual users to view only material that is new since their last visit to the site or limit search results to only those journals they have selected from the Virtual Journal. My Saved Searches allows users to save personalized searches to execute on demand without requiring the parameters to be re-entered each time.
Science Signaling: The Database of Cell Signaling
The Database of Cell Signaling contains information on signaling components and their relations. The data are organized into signaling pathways called Connections Maps and are provided by leading authorities in the field. The database organizes information and provides previously unavailable information, such as short lists of selected key references and the authorities' evaluations of the strength of existing evidence for relations in the database. The Connections Maps themselves are dynamically generated pathway diagrams that instantly reflect new information provided by the authorities.
Science Signaling: A Community
The electronic format of Science Signaling allows users to interact more easily with authors, researchers, experts, and colleagues. Forums provide users the opportunity to exchange views and information in topically organized threaded discussions. E-Letters allow readers to add their opinion to, point out new research about, or address the author of any specific original article in Science Signaling. Interactions among the cell signaling community are facilitated by the Directory, which includes contact information and descriptions about the interests of researchers, students, and others interested in cell signaling.
Science Signaling: A Portal to Online Resources
Science Signaling provides access to various online resources, including a search interface for Science Careers; an Events calendar of meetings, conferences, and workshops of interest to the signal transduction community; and ST NetWatch, which includes editorially reviewed descriptions and links to useful Web sites and online tools relevant to signaling research and education.
History of KEs
The American Association for the Advancement of Science (AAAS) established a collaboration with Stanford University Libraries (SUL) and The Center for Resource Economics/Island Press (Island Press) in 1996 to help scientific researchers and nonprofit organizations harness the power of the Internet and electronic publishing. At that time, only a handful of journals were available through the Internet, and the World Wide Web was in its infancy. It was clear, however, that the Web could transform the ways in which scientists gathered and shared information as part of research efforts. We recognized that Web-based technologies could enhance access to databased information and greatly improve the effectiveness of information transfer and the creation of new knowledge. Development work on the project began in early 1998 after the collaborative received a grant from The Pew Charitable Trusts to create a prototype of the Web-based electronic networking tools we envisioned.
Knowledge Environment (KE) is the term coined by the collaborative to describe the collection of electronic networking tools we are developing. KEs use practical, production-quality tools to systematize the consensus knowledge within a scientific domain and to facilitate users' access to that knowledge. In a KE, access occurs through searching, browsing, and current awareness features combined with user-friendly graphical interfaces. KEs combine primary and review literature with more dispersed sources of "how-to," "what-is," and "where-to" knowledge. Specific electronic tools that facilitate entry of information into the underlying databases continue to be developed as part of the concept.
Signal transduction research was selected for the prototype KE for several reasons.
The characteristics of the potential user base allow us to test many of the electronic tools that are central to the KE concept.
The user population is an interdisciplinary group, so we are able to test those KE tools that are specifically designed to facilitate communication across disciplines and to filter information such that only material relevant to the user's interest is presented.
The topic can be mapped by classes of data structures, which allows us to test the use of a graphical interface to access and display data from a database maintained by experts.
No single journal serves as the main source of signal transduction information; researchers must scan numerous sources to stay abreast of current advances. Thus, there is a clear need for information management tools.
The informal exchange of information within this research community is also fractured because signal transduction researchers do not all belong to one scholarly society.
Instructions to Authors
Science Signaling is a weekly journal that publishes original material pertaining to the broad field of cell signaling. As of September 2008, Science Signaling publishes original research, in addition to the previous features, which include Perspectives, Reviews, Protocols, Meeting Reports, Journal Club, Presentations, and Teaching Resources. Of these, most Perspectives and Reviews are solicited by the editors, but we welcome your suggestions of potential topics and authors. Detailed instructions are available as PDFs below the general overview of each type of manuscript.
Research Articles are expected to present a major advance in cell signaling research. They should include an abstract and be structured as follows: Introduction, Results, Discussion, and Materials and Methods. Supplementary Material is permitted but should be limited to information that is not essential to the understanding and evaluation of the research presented in the paper. See the Call for Papers for more details about the scope, review process, instructions for authors, and online submission.
Research Resources are selected from the Research Article submissions and describe nonhypothesis-driven research, including the presentation of new validated tools or techniques or validated databases or data sets relevant to cellular regulation. See the Research Resource help page for more information.
Perspectives emphasize the opinions or viewpoints of their authors. More limited in scope than Reviews, they may focus on recently published papers or on methods, books, or policy matters.
Meeting Reports, which were originally published as Perspectives, are now published as a separate category. Often written by the meeting organizers, they feature highlights from meetings and conferences related to cell signaling.
Reviews address timely topics of broad interest and of relevance to signal transduction. Unlike conventional reviews, they may be updated by their authors as developments warrant. Reviews are accompanied by 'glosses' -- textbook-level summaries for readers who seek a brief introduction to the topic. Reviews should provide new insights as well as summarize the information currently available. The best reviews reflect the unique viewpoint of the author and show how new findings alter current thinking about major issues in a particular field. Reviews are evaluated by peer review for scholarship, accuracy, clarity, and effectiveness of presentation. Reviews may provide comprehensive coverage of a topic or may be more tightly focused in the form of a mini-review.
Journal Club articles are short, lively overviews by graduate students or postdoctoral fellows that highlight recent exciting developments in cell signaling research.
Protocols provide step-by-step instructions and notes on the techniques of signal transduction research - information often only hinted at in 'Materials and Methods' sections. Protocols should provide the unique viewpoint and experiences of the author.
Presentations, which are part of the Community section, provide a text description along with the slides presented at a meeting or a seminar in the form of a slideshow.
Teaching Resources, which are part of the Resources section, can be animations, movies, sample questions, lecture materials, online tutorials, or other resources that may be useful for teaching courses that include topics related to signal transduction and cellular regulation. Each includes an abstract, a text description of the resource that includes information for indexing these materials at the BioSciEdNet, a catalog of digital resources useful for teaching biology. Although many of these resources are created or submitted with Science Signaling articles or Connections Maps, the pathways in the Database of Cell Signaling, contributions are welcome. If you have resources that you believe would be appropriate and valuable for the teaching community, please send the Editors a message.
Detailed Instructions for Authors
Research Articles and Research Resources: Initial Submission or Revised Manuscripts
Perspectives, Meeting Reports, and Book Reviews
Reviews
Mini-Reviews
Journal Club
Protocols
Presentations
General Information Regarding Manuscript Preparation
Symbols, abbreviations, and acronyms should be defined the first time they are used.
Units of measure should be given in SI units. If measurements were made in English units, give metric equivalents.
References and notes are numbered in the order in which they are cited, first through the text and the references, then through the table and figure legends. List a reference only one time. Any references to in-press manuscripts or personal communications should be given a number in the text and placed, in correct sequence, in the references and notes. Such references should not, however, be used to support claims or conclusions. Do not use op. cit., ibid., or et al. (in place of the complete list of authors' names). Journal article references should be complete, including the complete list of authors, the full titles, and the inclusive pagination. Detailed information is provided in the detailed instructions for authors for each type of manuscript.
Figures and tables may be included with any type of manuscript. All figures must be called out within the text. Figures should be numbered in the order of their citation in the text. Details about figure and table preparation are included in the detailed instructions for authors, as they vary by manuscript type.
Figure Legends should be included in the text file immediately after the body of the text and preceding the references. Nomenclature, abbreviations, symbols, and units used in a figure should match those used in the text. The figure title should be given as the first line of the legend.
Tables should supplement, not duplicate, the text. They should be numbered in the order of their citation in the text. The first sentence of the legend should be a brief descriptive title. Each vertical column of a table should have a heading and if appropriate include the unit of measure in parentheses. Units should not change within a column. Centered headings of the body of the table can be used to break the entries into groups. Footnotes should contain information relevant to specific entries or parts of the table.
Supplementary Materials may include digital resources, large data sets, or video or audio files. These should be restricted to information that either not essential to understanding and evaluating the article or is not presentable in a printable format. All supplementary materials should be accompanied by a brief text description, similar to a caption. Details about preferred file formats and file sizes are included in the detailed instructions for authors.
Policies: Submission Requirements and Conditions of Acceptance
To meet its responsibility to readers and to the public to provide clear and unbiased scientific results and analyses, AAAS requires that all manuscripts published in Science, Science Signaling, and Science Translational Medicine are accompanied by clear disclosures from all authors of the nature and level of their contribution to the article, their understanding regarding the obligation to share data and materials, and any affiliations, funding sources, or financial holdings that might raise questions about possible sources of bias. Before manuscript acceptance, therefore, authors will be asked to sign an authorship and conflict of interest form.
Science Signaling Authorship and Conflict of Interest Form
The policies for publication of original research in Science Signaling follows those for publication of research in Science (see the Submission Requirement and Conditions of Acceptance on the Science instructions for authors). These are briefly described here with reference to the appropriate pages on the Science instructions for authors.
Authorship All authors must agree to be so listed and must have seen and approved the manuscript, its content, and its submission to Science Signaling. Any changes in authorship must be approved in writing by all of the original authors. Submission of a paper that has not been approved by all authors will result in immediate rejection without appeal.
Prior publication Science Signaling will not consider any paper or component of a paper that has been published or is under consideration elsewhere. Distribution on the Internet may be considered prior publication and may compromise the originality of the paper. Please contact the editors with questions regarding this policy.
Human studies Informed consent must have been obtained for studies on humans after the nature and possible consequences of the studies were explained. All research on humans must have approval from the author's Institutional Review Board (IRB) or equivalent body.
Animal care Care of experimental animals must be in accordance with the authors?institutional guidelines.
Related papers Copies of papers submitted to other journals by any of the authors that relate to a research article submitted to Science Signaling must be included with the submission.
Unpublished data and personal communications Citations to unpublished data and personal communications cannot be used to support claims in the paper.
Funding and conflict of interest Authors must agree to disclose all affiliations, funding sources, and financial or management relationships, including those that could be perceived as potential sources of bias. Science Signaling follows the same policy as that of Science (see http://www.sciencemag.org/about/authors/prep/coi.dtl).
Data deposition Before publication, large data sets, including microarray data, protein or DNA sequences, and atomic coordinates and structure factors for macromolecular or chemical structures must be deposited in an approved database, an accession number must be included in the published paper, and the deposited information must be released at the time of publication. Electron micrograph maps must also be deposited. Science Signaling follows the same guidelines as those for Science (see Data deposition).
License Authors retain copyright but must agree to grant to Science Signaling an exclusive license to publish the paper in print and online.
Data availability After publication, all data necessary to understand and assess the conclusions of the manuscript must be available to any reader of Science Signaling. Science Signaling follows the same guidelines as those for Science (see Data availability).
Access policies After publication, authors may post the accepted version of the paper on the author抯 personal Web site and are provided one referrer link that can be posted on a personal or institutional Web page, through which users can freely access the published paper on the Science Signaling site. Science Signaling allows deposition of accepted peer-reviewed articles (Research Articles, Reviews, and Protocols) into the NIH PubMed Central or other PMC International repository 6 months after publication, in accord with the requirements of the funders NIH and Wellcome Trust, provided that a link to the final version published in Science Signaling is included. Original research papers will be freely accessible with registration at Science Signaling 12 months after publication.
Materials sharing After publication, all reasonable requests for materials must be fulfilled. Before acceptance, Science Signaling must be informed of any restrictions on sharing of materials [Material Transfer Agreements (MTAs), for example]. Unreasonable restrictions may preclude publication.
Embargo policy The paper will remain a privileged document and will not be released to the press or the public before publication. Questions should be referred to the AAAS Office of Public Programs (202-326-6440).
Electronic Submission
Authors of invited submissions will be sent information about online submission by the Science Signaling editor. If you wish to contribute an article that has not been invited by the editors, please contact the editors for information about online submission.
Primary research articles may be submitted online www.submit2SciSignal.org.
Detailed information about filenaming conventions, file sizes, and acceptable file formats is included in the detailed instructions for authors of each type of manuscript.
Editorial Board
Chief Scientific Editor
Michael B. Yaffe
David H. Koch Institute for Integrative Cancer Research
Departments of Biology and Biological Engineering
Massachusetts Institute of Technology
Cambridge, MA, USA
Editorial Board, Board of Reviewing Editors, and Bioinformatics Committee
K. Mark Ansel#
Department of Microbiology and Immunology
University of California, San Francisco
San Francisco, CA, USA
Greg Barton#
Department of Molecular and Cell Biology
University of California, Berkeley
Berkeley, CA, USA
John Blenis#
Department of Cell Biology
Harvard Medical School
Boston, MA, USA
Lewis C. Cantley*#^
Division of Signal Transduction
Beth Israel Deaconess Medical Center
Boston, MA, USA
Joanne Chory#
Plant Molecular and Cellular Biology Laboratory
Salk Institute
La Jolla, CA, USA
Ivan Dikic#
Institute of Biochemistry II
Goethe University Medical System
D-60590 Frankfurt am Main, Germany
Henrik Dohlman#
Department of Biochemistry and Biophysics
The University of North Carolina Chapel Hill
Chapel Hill, NC, USA
George Dubyak#
Department of Physiology and Biophysics
Case Western Reserve University
Cleveland, OH, USA
Joseph Ecker*^
Plant Molecular and Cellular Biology Laboratory
Salk Institute
La Jolla, CA, USA
Lee E. Eiden*#^
Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation
National Institute of Mental Health
Bethesda, MD, USA
Raymond L. Erikson#
Department of Molecular & Cellular Biology
Harvard University
Cambridge, MA, USA
Ronald M. Evans#
Molecular and Developmental Biology Laboratory
Salk Institute
La Jolla, CA, USA
James Faeder#
Department of Computational and Systems Biology
University of Pittsburgh School of Medicine
Pittsburgh, PA, USA
David Fruman#
Department of Molecular Biology and Biochemistry
University of California
Irvine, CA, USA
Frank B. Gertler#
David H. Koch Institute for Integrative Cancer Research
Department of Biology
Massachusetts Institute of Technology
Cambridge, MA, USA
Sankar Ghosh#
Department of Microbiology and Immunology
Columbia University
New York, NY, USA
Tony Hunter*#^
Molecular and Cell Biology Laboratory
Salk Institute
La Jolla, CA, USA
Ravi Iyengar*#^
The Dorothy H. and Lewis Rosenstiel Department of Pharmacology and Biological Chemistry
Mount Sinai School of Medicine
New York, NY, USA
Lily Jan#
Howard Hughes Medical Institute
University of California, San Francisco
San Francisco, CA, USA
Michael Klagsbrun#
Department of Surgery
Harvard Medical School
Boston, MA, USA
Andre Levchenko#
Signal Transduction and Cell-Cell Communication Lab
The Whitaker Institute for Biomedical Engineering
Baltimore, MD, USA
Beth Levine#
Howard Hughes Medical Institute
University of Texas Southwestern Medical Center
Dallas, TX, USA
Terry Magnuson#
Department of Genetics
University of North Carolina School of Medicine
Chapel Hill, NC, USA
James Malter#
Department of Pathology and Laboratory Medicine
University of Wisconsin-Madison
Madison, WI, USA
Gerard Manning^
Razavi-Newman Center for Bioinformatics
Salk Institute
La Jolla, CA, USA
Seamus J. Martin#
Smurfit Institute of Genetics
Trinity College
Dublin, Ireland
Jill Mesirov#
Computational Biology and Bioinformatics
Broad Institute
Cambridge, MA, USA
Tobias Meyer#
Chemical and Systems Biology
Stanford University Medical Center
Stanford, CA, USA
Katsuhiko Mikoshiba*#
Laboratory for Developmental Neurobiology
RIKEN Brain Science Institute
Tokyo, Japan
Marc R. Montminy#
Clayton Foundation Laboratories for Peptide Biology
Salk Institute for Biological Studies
San Diego, CA, USA
Randall T. Moon*#^
Howard Hughes Medical Institute and Department of Pharmacology
University of Washington
Seattle, WA, USA
Carl Nathan#
Department of Microbiology and Immunology and Department of Medicine
Weill Cornell Medical College
New York, NY, USA
Benjamin G. Neel#
Division of Stem Cell and Developmental Biology
Ontario Cancer Institute
Toronto, ON, Canada
Gabriel Nuñez#
Department of Pathology
University of Michigan Health System
Ann Arbor, MI, USA
Michele Pagano#
Department of Pathology and NYU Cancer Institute
New York University School of Medicine
New York, NY, USA
Carole Parent*#^
Laboratory of Cellular and Molecular Biology
National Cancer Institute, National Institutes of Health
Bethesda, MD, USA
Norbert Perrimon#
Department of Genetics
Harvard Medical School
Boston, MA, USA
Rama Ranganathan#
Green Center for Systems Biology
Department of Pharmacology
University of Texas Southwestern Medical Center
Dallas, TX, USA
Anne Ridley#
Randall Division of Cell and Molecular Biophysics
King's College London
London, UK
David Root#
Genome Biology and Cell Circuits Program, Broad Institute of MIT and Harvard
Massachusetts Institute of Technology
Cambridge, MA, USA
Joseph Schlessinger*#^
Department of Pharmacology
Yale University School of Medicine
New Haven, CT, USA
Solomon Snyder*#
Department of Neuroscience
Johns Hopkins University
Baltimore, MD, USA
Jean-Paul Vincent#
MRC National Institute for Medical Research
London, UK
Eric Vivier*#
Centre d`Immunologie de Marseille-Luminy
INSERM-CNRS-Univ. Mediterranee
France
John C. Walker#
Interdisciplinary Plant Group
University of Missouri-Columbia
Columbia, MO
Nancy Walworth*#
Department of Pharmacology
Robert Wood Johnson Medical School and Rutgers
Piscataway, NJ, USA
Jeffrey Wrana#
Samuel Lunenfeld Research Institute
Toronto, Ontario, CA
Gary Yellen#
Department of Neurobiology
Harvard Medical School
Boston, MA, USA
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